High Throughput Enzymatic Enantiomeric Excess: Quick-ee
نویسندگان
چکیده
منابع مشابه
EMDee: an enzymatic method for determining enantiomeric excess.
The techniques of combinatorial chemistry have recently been applied to the discovery of new asymmetric catalysts for a variety of organic transformations.1 These techniques are useful for increasing the efficiency by which chiral ligands for metal catalysts are discovered since the design of these ligands is largely an empirical process, and there are currently no simple rules for reliably pro...
متن کاملSynthesis of highly epimerizable N-protected -amino aldehydes of high enantiomeric excess
The Dess–Martin periodinane was found to be a superior oxidant for the efficient, epimerization-free synthesis of optically active N-protected -amino aldehydes from the corresponding N-protected -amino alcohols. Highly racemization-prone products, including N-Fmoc phenylglycinal and N-trifluoroacetyl -amino aldehydes, were prepared in 95% yield with 1% epimerization. © 2000 Elsevier Science Ltd...
متن کاملChemical and enzymatic synthesis of tRNAs for high-throughput crystallization.
Preparation of large quantities of RNA molecules of a defined sequence is a prerequisite for biophysical analysis, and is particularly important to the determination of high-resolution structure by X-ray crystallography. We describe improved methods for the production of multimilligram quantities of homogeneous tRNAs, using a combination of chemical synthesis and enzymatic approaches. Transfer ...
متن کاملSensing of enantiomeric excess in chiral carboxylic acids.
Cinchona alkaloids (quinine, quinidine, cinchonine, cinchonidine) alkylated at N(1) with chloromethyl anthracene can serve as fluorescent sensors for chiral carboxylic acids. These cinchona ammonium salts are shown to bind chiral carboxylic acids while displaying an increase in fluorescence intensity that can be utilized in determination of enantiomeric excess (ee). Sensor arrays composed of fo...
متن کاملHigh temperature sublimation of α-amino acids: a realistic prebiotic process leading to large enantiomeric excess.
The reiterative high temperature co-sublimation of an enantiopure or an enantioenriched α-amino acid mixed with racemic α-amino acids leads to deracemization of the latter. A synergistic effect is observed for complex mixtures, and the sense of the handedness is, for all compounds, identical to that of the enantioenriched starting material.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the Brazilian Chemical Society
سال: 2014
ISSN: 0103-5053
DOI: 10.5935/0103-5053.20140282